‘Biomarkers and mediators of diseases’
POLISH-FRENCH LABORATORY

 

 

The international associated laboratory ‘MicroRNAs: novel biomarkers of tumor angiogenesis’ (LIA ‘MiR-TANGo’) has been established between the Department of Medical Biotechnology of the Jagiellonian University Faculty of Biochemistry, Biophysics and Biotechnology and the team of Cell Recognition and Glycobiology of CNRS in Orleans. The agreement has been signed on May 29, 2013 in Krakow.

This first LIA in life sciences in Poland was located at the Department of Medical Biotechnology and in the new premises of the Małopolska Centre for Biotechnology. The aim of LIA MirTANGO was research on mechanisms of cancer growth and search for new ways of treating cancer, based on modern innovative therapies. The LIA resulted from the ten-year collaboration of both teams that had already realised several joint research projects, supervised three joint PhDs, several dozen Master’s theses, numerous conferences and workshops as well as new research models and publications in prestigious international periodicals. The laboratory was directed by Prof. Józef Dulak and Prof. Claudine Kieda.

After four successful years the LIA team has renewed the application to CNRS and the extension of LIA for the 2017-2020 has been awarded by CNRS. The LIA will now work on the “Biomarkers and mediators of diseases” (under the acronym miRTangO-BIS), coordinated by prof. Józef Dulak and prof. Eva Jakab-Toth.

 

Contact

Poland                                               France

Jozef Dulak                                     Eva Jakab Toth
email: jozef.dulak@uj.edu.pl               email: eva.jakabtoth@cnrs.fr
phone: +48 12 664 6375                    phone: +33 238 25 76
fax. +48 12 664 6918                         fax. +33 238 63 15

 

Polish - French Workshop „Biomarkers and mediators of diseases-new approaches in repair/regenerative therapies”, Warsaw 2019

The LIA workshop was held on 4-5 June in Warsaw. This time the meeting was co-organized by the Military Institute of Medicine (LOMTI - Laboratory of Molecular Oncology and Other Therapy), CNRS (CBM-Center de Biophysique Moleculaire) and the Department of Medical Biotechnology FBBB JU.

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Polish - French Workshop, “Biomarkers and mediators of diseases” , Kraków, 2018

A workshop was held on May 30 to 1 June in Orléans. As part of the meeting, achievements in research on new mechanisms and biomarkers of cancer diseases, cardiovascular diseases, inflammatory diseases in Poland and in the world were presented, with particular emphasis on research conducted at FBBB UJ.                  

 

 

Polish - French Workshop, “Biomarkers and mediators of diseases” , Kraków, 2017

On 26th and 27th June at the FBBB, Polish – French workshop was held to summarize the four-year collaboration (2013-2016) between the Department of Medical Biotechnology and the Molecular Biophysics Center (CNRS) in Orléans under the International Associated Laboratory (LIA).


Workshop of the International Associated Laboratory CNRS-Jagiellonian University 2013-2016

Polish - French Workshops are conducted within the agreement of scientific collaboration that embraces a series of scientific meetings of research teams from Poland and France.  

    Paris, 2013                                         Kraków, 2014                                   Orleans, 2016

                                                             

 

Publications in the frame of LIA

(both collaborative Polish-French and on related subjects published  by the Polish team)

  • Klimkiewicz K, Weglarczyk K, Collet G, Paprocka M, Guichard A, Sarna M, Jozkowicz A, Dulak J, Sarna T, Grillon C, Kieda C.A 3D model of tumour angiogenic microenvironment to monitor hypoxia effects on cell interactions and cancer stem cell selection. Cancer Lett. 2017 Jun 28;396:10-20. doi: 10.1016/j.canlet.2017.03.006.
  • Ciesla M, Marona P, Kozakowska M et al;  Dulak J, Jozkowicz  A. Heme oxygenase-1 controls an HDAC4-miR-206 pathway of oxidative stress in rhabdomyosarcoma. Cancer Res, 2016 Oct 1;76(19):5707-5718
  • Oszajca M, Collet G, Stochel G, Kieda C, Brindell M, Hypoxia-selective inhibition of angiogenesis development by NAMI-A analogues. Biometals 2016: 29: 1035-1046.
  • Loboda A, Damulewicz M, Pyza E, Jozkowicz A, Dulak J. Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionary conserved mechanism. Cell Mol Life Sci 2016 Sep;73(17):3221-47
  • Kozakowska M, Dobrowolska-Glazar B, Okoń K, Józkowicz A, Dobrowolski Z, Dulak J. Preliminary Analysis of the Expression of Selected Proangiogenic and Antioxidant Genes and MicroRNAs in Patients with Non-Muscle-Invasive Bladder Cancer. J Clin Med 2016 Feb 25;5(3). Pii: E29. doi: 10.3390/jcm5030029.
  • Papież MA, Krzyściak W, Szade K, Bukowska-Straková K, Kozakowska M, Hajduk K, Bystrowska B, Dulak J, Jozkowicz A Curcumin enhances the cytogenotoxic effect of etoposide in leukemia cells through induction of reactive oxygen species. Drug Des Devel Ther. 2016 Feb 4;10:557-70. doi: 10.2147/DDDT.S92687. eCollection 2016.
  • Loboda A, Jozkowicz A, Dulak J. HO-1/CO system in tumor growth, angiogenesis and metabolism - Targeting HO-1 as an anti-tumor therapy. Vascul Pharmacol. 2015; 74: 11-22.
  • Collet G,   Szade K,  Nowak W,  Klimkiewicz K,  El Hafny-Rahbi B,   Szczepanek K,   Sugiyama D,  Weglarczyk K,   Foucault-Collet A,   Guichard A,   Mazan A,   Nadim M,  Fasani F,   Lamerant-Fayel N,   Grillon C,   Petoud S,   Beloeil J-C,  Jozkowicz A,  Dulak J,   Kieda C. Endothelial precursor cell-based therapy to target the pathologic angiogenesis and compensate tumor hypoxia. Cancer Lett. 2016 Jan 28;370(2):345-57. doi: 10.1016/j.canlet.2015.11.008.  
  • Tertil M, Golda  S.,  Skrzypek  K,   Florczyk  U,  Weglarczyk K,  Kotlinowski J, Maleszewska M,  Czauderna S, Pichon C,  Kieda  C,  Jozkowicz A,  Dulak J. Nrf2-heme oxygenase-1 axis in mucoepidermoid carcinoma of the lung: antitumoral effects associated with downregulation of matrix metalloproteinases, Free Radicals Biol Med, 2015 Sep 21;89:147-157. doi: 10.1016/j.freeradbiomed.2015.08.004
  • Szade K, Zukowska M,  Szade A, Collet G, Kieda C, Jozkowicz A, Dulak J. Spheroid-plug model as a tool to study tumor development, angiogenesis and heterogeneity in vivo. Tumor Biol, 2016 Feb;37(2):2481-96. doi: 10.1007/s13277-015-4065-z. Epub 2015 Sep 18.    
  • Collet G, Lamerant-Fayel N, Tertil M, El Hafny-Rahbi B, Stepniewski J, Guichard A, Foucault-Collet A, Klimkiewicz K, Petoud S, Matejuk A, Grillon C, Jozkowicz A, Dulak J, Kieda C. Hypoxia-regulated over expression of soluble VEGFR2 controls angiogenesis and inhibits tumor growth. Mol Cancer Ther. 2014 Jan;13(1):165-78. doi: 10.1158/1535-7163.MCT-13-0637.
  • Tertil M, Skrzypek K, Florczyk U, Weglarczyk K, Was H, Collet G, Guichard A, Gil T, Kuzdzal J, Jozkowicz A, Kieda C, Pichon C, Dulak J. Regulation and novel action of thymidine phosphorylase in non-small cell lung cancer: crosstalk with Nrf2 and HO-1. PLoS One. 2014 May 12;9(5):e97070. doi: 10.1371/journal.pone.0097070.
  • C. Kieda, B. El Hafny-Rahbi, G.Collet, N.Lamerant-Fayel, C. Grillon, A.Guichard, J. Dulak, A. Jozkowicz, J. Kotlinowski, K.C. Fylaktakidou, A.Vidal, P. Auzeloux, E. Miot-Noirault , J-C. Beloeil, J-M. Lehn, C.Nicolau, Stable tumor vessel normalization with pO2 increase and endothelial PTEN activation by inositol tris pyrophosphate brings novel tumor treatment. J Mol Med (Berl). 2013 Mar 9, 2013 July; 91(7): 883–899.
  • Skrzypek K, Tertil M, Golda M, Ciesla M, Weglarczyk K, Collet G, Guichard A, Kozakowska M, Boczkowski J, Was H, Gil T, Kuzdzal J, Muchova L, Vitek L, Loboda A, Jozkowicz A, Kieda C, Dulak J, Interplay between heme oxygenase-1 and miR-378 affects non-small cell lung carcinoma growth, vascularization and metastasis. Antioxid Redox Signal. 2013 Sep 1;19(7):644-60. doi: 10.1089/ars.2013.5184. Epub 2013 Jun 27.